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KMID : 0359720100280010056
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Journal of the Korean Neurological Association
2010 Volume.28 No. 1 p.56 ~ p.58
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An Autopsy Case of Multiple System Atrophy
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Lee Jung-Hwan
Song Sook-Keun
Kim Sang-Kyum
Kim Tai-Seung
Lee Phil-Hyu
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Abstract
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Multiple-system atrophy (MSA) is an adult-onset, sporadic, progressive neurodegenerative disease. Clinically, the cardinal features include autonomic failure, parkinsonism, cerebellar ataxia, and pyramidal signs in any combination, of which autonomic failure is an integral component in the diagnosis. Pathologically, MSA is characterized by α-synuclein-positive glial cytoplasmic inclusions and neuronal loss, predominantly in the basal ganglia, brainstem, cerebellum, and intermediolateral cell columns of the spinal cord. We report the first case of MSA confirmed by autopsy in Korea.
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KEYWORD
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Multiple-system atrophy, Autopsy, Glial cytoplasmic inclusion
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